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Activation of the farnesoid X receptor represses PCSK9 expression in human hepatocytes
Authors:Langhi Cédric  Le May Cédric  Kourimate Sanae  Caron Sandrine  Staels Bart  Krempf Michel  Costet Philippe  Cariou Bertrand
Affiliation:INSERM, U915, CHU H?tel Dieu, NORD, Nantes F-44000, France.
Abstract:
Keywords:BA, bile acid   CA, cholic acid   CDCA, chenodeoxycholic acid   DCA, deoxycholic acid   FXR, farnesoid X receptor   IHH, immortalized human hepatocytes   LA, lithocholic acid   LDL-c, low density lipoprotein cholesterol   LDLr, low density lipoprotein receptor   PCSK9, pro-protein convertase subtilisin/kexin 9   PXR, pregnane X receptor   UDCA, ursodeoxycholic acid
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