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Presenilin 1 modifies lipid raft composition of neuronal membranes
Authors:Gunter P. Eckert,Walter E. Mü  ller
Affiliation:Department of Pharmacology, ZAFES, Campus Riedberg, Biocenter Niederursel, University of Frankfurt, N260, Max-von-Laue Str. 9, 60438 Frankfurt, Germany
Abstract:Protein-lipid interactions in the nervous system may provide insight into the causes of neurological disorders. In this study, we elucidated if expression of human presenilin 1 (PS1) in a mouse model changes the physico-chemical properties of brain membranes. PS1 is a multifunctional transmembrane protein and part of the γ-secretase complex. This complex is critical for the production of the Alzheimer related amyloid beta peptide. Brain membranes isolated from mice expressing a human wild-type PS1 transgene are less fluid and contain higher cholesterol and sphingomyelin levels. Moreover, our data reveal significant changes in membrane micro-domains and indicate that PS1 induces the formation of lipid rafts.
Keywords:Lipid raft   Alzheimer   Presenilin   Membrane micro-domain   γ-Secretase   Cholesterol   Membrane   Fluidity   Amyloid-precursor protein
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