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Comparison of sex-steroid synthesis between neonatal and adult rat hippocampus |
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| Authors: | Shimpei Higo Yasushi Hojo Hirotaka Ishii Kohei Nakajima Tetsuya Kimoto |
| Affiliation: | a Department of Biophysics and Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro, Tokyo 153-8902, Japan b Core Research for Evolutional Science and Technology Project of Japan Science and Technology Agency, The University of Tokyo, Japan c Bioinformatics Project of Japan Science and Technology Agency, The University of Tokyo, Japan d Medicinal Chemistry Division, Oncology and Molecular Endocrinology Research Center, Centre Hospitalier, Universitaire de Quevec Que., Canada G1V 4G2 |
| Abstract: | Sex-steroid synthesis in the hippocampus had been thought to be much more active at the neonatal stage than at the adult stage. However, the detailed comparison between these two stages had not been demonstrated yet. Here we performed the comparison about the mRNA level of steroidogenic enzymes and the rate of steroid metabolism between these two stages of the hippocampus. The relative expression level of P450(17α), 17β- or 3β-hydroxysteroid dehydrogenase, or P450arom was approximately 1.3-1.5-fold higher at the neonatal than at the adult stage. The rate of sex-steroid metabolism (from dehydroepiandrosterone to estradiol) was 2-7-fold (depending on different steps) more rapid at the neonatal than at the adult stage. Taken together, neonatal steroidogenesis is moderately more active than adult steroidogenesis. |
| Keywords: | ADione, androstenedione ADiol, androstenediol DHEA, dehydroepiandrosterone DHT, dihydrotestosterone E2, estradiol E1, estrone PREG, pregnenolone PROG, progesterone T, testosterone |
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