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| 青少年双生子体型指征相关指标的遗传度研究(英文) | |
| 引用本文： | 张栋,逄增昌,汪韶杰,宁峰,吴伟峰,兰金凤,张东. 青少年双生子体型指征相关指标的遗传度研究(英文)[J]. 现代生物医学进展, 2010, 10(3) |
| 作者姓名： | 张栋 逄增昌 汪韶杰 宁峰 吴伟峰 兰金凤 张东 |
| 作者单位： | 1. 青岛大学医学院营养研究所,山东,青岛,266021 2. 青岛市疾病预防控制中心 3. 芬兰赫尔辛基大学,公共卫生系 4. 青岛大学医学院,山东 青岛 |
| 摘 要： | 目的:用经典的双生子设计探讨遗传因素对青少年身高、体重、体质指数(BMI)等体型指征的影响程度。方法:从青岛市双生子库中选择自愿参加本研究的362对11-19岁双生子,测量身高、体重。同性别的双生子通过16个多态标记进行卵型鉴定,在此基础上,应用Mx软件构建结构方程模型分析计算遗传度。结果:对362对有效双生子数据进行分析,其中同卵双生子194对,异卵双生子168对,身高的最佳拟合模型ACE模型,体重和BMI的最佳拟合模型为AE模型。调整年龄性别后,身高的遗传度为66%,体重的遗传度为84%,体质指数的遗传度为75%。结论:在青少年体型指征的相关指标中,身高、体重、BMI受遗传因素影响都较大。 |
| 关 键 词： | 青少年双生子 遗传度 结构方程模型 体型指征 |
Heritability Analysis of Body Size Indices for Adolescent Twins |
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| ZHANG Dong,PANG Zeng-chang,WANG Shao-jie,NING Feng,WU Wei-feng,LAN Jin-feng,ZHANG Dong-feng. Heritability Analysis of Body Size Indices for Adolescent Twins[J]. Progress in Modern Biomedicine, 2010, 10(3) | |
| Authors: | ZHANG Dong PANG Zeng-chang WANG Shao-jie NING Feng WU Wei-feng LAN Jin-feng ZHANG Dong-feng |
| Affiliation: | ZHANG Dong1,PANG Zeng-chang2,WANG Shao-jie2,NING Feng4,WU Wei-feng3,LAN Jin-feng1,ZHANG Dong-feng3 (1 Institute of Nutrition,Qingdao University Medical College,Qingdao 266021,China,2 Qingdao Municipal Centers for Disease Control , Prevention,3 Qingdao University Medical College,4 Department of Public Health,University of Helsinki,Helsinki,Finl, ) |
| Abstract: | Objective:To investigate the impact of inheritance on height, weight and body mass index (BMI) in adolescent by the classic twin design. Methods:362 pairs of twins aged 11-19 years old were recruited from the Qingdao Twin Registry. Height, weight were measured. Zygosity in all same-sex twin pairs was determined by 16 polymorphic markers. Heritability was assessed by structural equation models. Results:362 pairs, including 194 pairs of monozygotic twins and 168 pairs of dizygotic twins, were choosen,. The AC... |
| Keywords: | Adolescent twins Heritability Structural equation models Body size indices |
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