Classification of the insulin-like growth factor binding proteins into three distinct categories according to their binding specificities |
| |
| Authors: | B Forbes L Szabo R C Baxter F J Ballard J C Wallace |
| |
| Institution: | Department of Biochemistry, University of Adelaide, Australia. |
| |
| Abstract: | Competitive binding experiments with insulin-like growth factor (IGF)-1, IGF-2 and des-(1-3)-IGF-1 have confirmed the interpretation based on limited amino-terminal sequence analysis that at least three types of IGF binding protein occur. In addition to the acid stable subunit of the large serum binding protein which exhibits des-(1-3)-IGF-1 binding only slightly less than IGF-1, the small IGF binding proteins can be separated into two classes based on differences in des-(1-3)-IGF-1 and IGF-2 binding potencies. |
| |
| Keywords: | |
|
|
