In vitro studies of gonadal organogenesis in the presence and absence of H-Y antigen |
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Authors: | Susumu Ohno Yukifumi Nagai Salvatrice Ciccarese Richard Smith |
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Institution: | (1) Department of Biology, City of Hope National Medical Center, 1500 East Duarte Road, 91010 Duarte, California |
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Abstract: | Summary In a very strict sense, the primary (gonadal) sex of mammals is determined not so much by the presence or absence of the Y
but the expression or nonexpression of the evolutionary extremely conserved plasma membrane H-Y antigen. The central somatic
blastema of embryonic indifferent gonads contains one cell lineage characterized by the possession of S−F differentiation
antigen that differentiates into testicular Sertoli cells in the presence of H-Y and into ovarian follicular (granulosa) cells
in its absence. This cell lineage appears to play the most critical role in gonadal differentiation. Whether or not testicular
Leydig cells and ovarian theca cells are similarly derived from the common cell lineage has not been determined. Nevertheless,
if given H-Y antigen, presumptive theca-cell precursors of the fetal ovary acquire hCG (LH?)-receptors—the characteristic
of fetal Leydig cells.
Presented in the formal symposium on Sexual Differentiation in Vitro and in Vivo at the 29th Annual Meeting of the Tissue
Culture Association, Denver, Colorado, June 4–8, 1978.
This work was supported by Contract NO1-CB-33907, and Grants No. 1 RO1 AG00042 and No. 5 RO1 CA16952 from the National Institutes
of Health. |
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Keywords: | primary (gonadal) sex determining mechanism secondary (extragonadal) sex determining mechanism H-Y antigen testis-organizing gonad-specific H-Y antigen-receptor Daudi human male Burkitt lymphoma cells β 2-m(— ) HLA(− ) S− F (Sertolifollicular) differentiation antigen |
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