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KIBRA (WWC1) Is a Metastasis Suppressor Gene Affected by Chromosome 5q Loss in Triple-Negative Breast Cancer
Authors:Jennifer F. Knight  Vanessa Y.C. Sung  Elena Kuzmin  Amber L. Couzens  Danielle A. de Verteuil  Colin D.H. Ratcliffe  Paula P. Coelho  Radia M. Johnson  Payman Samavarchi-Tehrani  Tina Gruosso  Harvey W. Smith  Wontae Lee  Sadiq M. Saleh  Dongmei Zuo  Hong Zhao  Marie-Christine Guiot  Ryan R. Davis  Jeffrey P. Gregg  Morag Park
Affiliation:1. Goodman Cancer Research Centre, McGill University, Montreal, QC H3G 0B1, Canada;2. Department of Biochemistry, McGill University, Montreal, QC H2W 1S6, Canada;3. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada;4. Department of Oncology, McGill University, Montreal, QC H2W 1S6, Canada;5. Department of Biomedical Engineering, McGill University, Montreal, QC H3A 2B4, Canada;6. Montreal Neurological Institute, Department of Pathology, McGill University, Montreal, QC H3A 2B4, Canada;7. Department of Pathology and Laboratory Medicine, University of California at Davis School of Medicine, Sacramento, CA 95817, USA;8. Department of Chemical Engineering, McGill University, Montreal, QC H3A 0C5, Canada;9. Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada
Abstract:
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  • Keywords:mechanotransduction  RHOA signaling  triple-negative breast cancer  metastasis  tumorspheres  chr5q
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