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Bimodal CD40/Fas-Dependent Crosstalk between iNKT Cells and Tumor-Associated Macrophages Impairs Prostate Cancer Progression
Authors:Filippo Cortesi  Gloria Delfanti  Andrea Grilli  Arianna Calcinotto  Francesca Gorini  Ferdinando Pucci  Roberta Lucianò  Matteo Grioni  Alessandra Recchia  Fabio Benigni  Alberto Briganti  Andrea Salonia  Michele De Palma  Silvio Bicciato  Claudio Doglioni  Matteo Bellone  Giulia Casorati  Paolo Dellabona
Affiliation:1. Experimental Immunology Unit, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan 20123, Italy;2. Center for Genome Research Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy;3. PhD Program of Molecular and Translational Medicine, Department of Medical Biotechnology and Translational Medicine, University of Milan, 20090 Segrate, Italy;4. Cellular Immunology Unit, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan 20123, Italy;5. Torque Therapeutics Inc., Cambridge, MA 02142, USA;6. Division of Pathology, San Raffaele Scientific Institute, Milan 20123, Italy;7. Centre for Regenerative Medicine, Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy;8. Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan 20123, Italy;9. San Raffaele Vita-Salute University, Milan 20123, Italy;10. Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
Abstract:
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  • Keywords:iNKT cells  CD1d  macrophage  tumor microenvironment  prostate cancer  immunotherapy  CD40  Fas  angiogenesis
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