Evolution of the Zfx and Zfy genes: rates and interdependence between the genes |
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Authors: | Pamilo P; Bianchi NO |
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Institution: | Department of Genetics, Uppsala University, Sweden. |
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Abstract: | A phylogenetic analysis of sex-chromosomal zinc-finger genes (Zfx and Zfy)
indicates that the genes have not evolved completely independently since
their initial separation. The sequence similarities suggest gene conversion
in the last exon between the duplicated Y-chromosomal genes Zfy-1 and Zfy-2
in the mouse. There are also indications of conversion (or recombination)
between the X- and Y-chromosomal genes in the crab- eating fox and in the
mouse. The method for estimating synonymous and nonsynonymous substitutions
is modified by incorporating the substitutions in the twofold-degenerate
sites in a novel way. The estimates of synonymous substitutions support the
generation-time hypothesis in that the obtained rates are higher in mice
(by a factor of 4.7) than in humans and higher in the Y-chromosomal genes
(by a factor of 1.9) than in the X-chromosomal genes.
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