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Grave's disease affecting one thyroid lobe: About 2 cases
Institution:1. Department of Nuclear Medicine, European & Center for Research in Medical Imaging, Aix-Marseille University, 13385 Marseille, France;2. Service de médecine nucléaire, centre cardiologique du Nord, 93200 Saint-Denis, France;3. Service de médecine nucléaire, CHU de Grenoble, 38700 La-Tronche, France;4. Service de médecine nucléaire, CHU de Henri-Mondor, 94010 Créteil, France;5. Ligue contre le cancer, France;6. Service de médecine nucléaire, CHU de Cochin, 75014 Paris, France;7. Service de médecine nucléaire, CHU de Montpellier, 34090 Montpellier, France;8. Service de médecine nucléaire, CHU de Lille, 59000 Lille, France;9. Service de médecine nucléaire, institut de cancérologie privé, 34170 Castelnau-le-Lez, France;10. Service de médecine nucléaire, CH de Albi, 81000 Albi, France;11. Service de médecine nucléaire, AP–HM, 13005 Marseille, France;1. Department of Internal Medicine, School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil;2. Medical Student, School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil;3. Department of Internal Medicine, Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil;4. Department of Anatomy and Imaging, School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil;1. University of Health Sciences, Istanbul Training and Research Hospital, Department of Nuclear Medicine, ?stanbul, Turkey;2. University of Health Sciences, Istanbul Sultangazi Haseki Training and Research Hospital, Department of Neurology, ?stanbul, Turkey;1. Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, 200032 Shanghai, China;2. Department of Nuclear Medicine, Xiamen Branch, Zhongshan Hospital, Fudan University, 361015 Fujian, China;3. Nuclear Medicine Institute of Fudan University, 200032 Shanghai, China;4. Shanghai Institute of Medical Imaging, 200032 Shanghai, China;5. Department of Pathology, Zhongshan Hospital, Fudan University, 200032 Shanghai, China;1. Shanghai Institute of Medical Imaging, Shanghai 200032, China;2. Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, 180, Fenglin road, Shanghai 200032, China;3. Nuclear Medicine Institute of Fudan University, Shanghai 200032, China;4. Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Abstract:Graves’ disease is an autoimmune disorder of thyroid which is characterized by hyperthyroidism, diffuse goiter, ophthalmopathy. Due to the pathophysiological mechanism of the disease, the disease affects both thyroid lobes. Unilateral involvement of the thyroid gland in patients with Graves’ disease is a rare entity, which suggests a difference between the two thyroid lobes. Clarifying this phenomenon could be a line of research for a better understanding of the pathophysiology of Graves's disease. This entity must be known to the clinician in order to take it better and avoid misdiagnosis. Here we present two cases of Graves’ disease which had unilateral involvement of the thyroid gland and discuss the hypotheses explaining this observation.
Keywords:Graves diseases physiopathology  One thyroid lobe  Thyroid scintigraphy  Physiopathologie de la maladie de basedow  Un seul lobe  Scintigraphie thyroïdienne
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