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How Inflammasomes Inform Adaptive Immunity

Authors:	Charles L Evavold Jonathan C Kagan

Institution:	Division of Gastroenterology, Boston Children''s Hospital, Harvard Medical School, Boston, MA 02115, USA;Program in Immunology, Harvard Medical School, Boston, MA 02115, USA

Abstract:

Keywords:	inflammasomes innate immunity SMOC TLR adaptive immunity PAMPs pathogen-associated molecular patterns PRRs pattern recognition receptors DAMPs damage-associated molecular patterns APCs antigen-presenting cells DCs dendritic cells MHC major histocompatibility complex IL interleukin TLRs Toll-like receptors SMOC supramolecular organizing center Tregs T regulatory cells IFN-γ interferon-γ TCR T-cell receptor MS multiple sclerosis NK natural killer ROS reactive oxygen species PLY pneumolysin KO knock-out CFA complete Freund's adjuvant CNS central nervous system WNV West Nile virus EAE experimental autoimmune encephalomyelitis SLE systemic lupus erythematous dsDNA double-stranded DNA LPS lipopolysaccharide
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