| 用单克隆抗体研究鸡新城疫病毒抗原变异与流行病学的相关性 |
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| 引用本文： | 周维松,刘秀梵.用单克隆抗体研究鸡新城疫病毒抗原变异与流行病学的相关性[J].Virologica Sinica,1992(4). |
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| 作者姓名： | 周维松 刘秀梵 |
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| 作者单位： | 江苏农学院牧医系，江苏农学院牧医系 扬州 225001中国农科院生物中心北京 100081，扬州 225001 |
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| 基金项目： | 国家“七五”重点攻关项目 |
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| 摘 要： | 用19株抗鸡新城疫病毒(NDV)单克隆抗体(简称单抗)测定与14个NDV国际参考株和16个NDV国内分离株的反应性,将毒株分为a～h 8个群。该组单抗能较精细地测出流行病学上不同的毒株间的抗原变异,毒株分群显示了抗原变异与流行病学特征的相关性。
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| 关 键 词： | 鸡新城疫病毒 单克隆抗体 抗原变异 流行病学特征 |
Relativity Between Antigenic Variation and Epidemiologic Characters of Newcastle Disease Virus Strains Detected.by Monoclonal Antibodies |
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| Zhou Wei-song Liu Xiu-fan.Relativity Between Antigenic Variation and Epidemiologic Characters of Newcastle Disease Virus Strains Detected.by Monoclonal Antibodies[J].中国病毒学(英文版),1992(4). |
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| Authors: | Zhou Wei-song Liu Xiu-fan |
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| Abstract: | Nineteen monoelonal antibodies (McAb) specific for Newcastle Disease Virus (NDV)was produced and used for the reactivity detection to 14 international reference NDV strains and 16 domestic NDV isolates by indirect immunofluorescent assay (IIF) . According to the results, the 30 NDV strains was divided into 8 groups from a to h. The antigenic variation of the strains which are different in epidemiology could be estimated by IIP test using the 19 MeAbs. It was showed tl, at there is relativity between antigenic variation and epidemiologic characters of NDV strains by the grouping of the 30 NDV strains In addition, antigenic different virions were found to exist in Lasota strain. |
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| Keywords: | Newcastle disease virus Antigenic variation Epidemiology |
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