| 冷适应大鼠脑垂体,下丘脑,脾淋巴细胞和血浆β—内啡肽... |
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| 引用本文： | 徐扬,杨泽田.冷适应大鼠脑垂体,下丘脑,脾淋巴细胞和血浆β—内啡肽...[J].生理学报,1992,44(1):45-53. |
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| 作者姓名： | 徐扬 杨泽田 |
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| 摘 要： |
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| 关 键 词： | 冷适应 垂体 下丘脑 淋巴细胞 血浆 |
Changes in beta-endorphin and its messenger RNA in pituitary, hypothalamus, lymphocytes and blood plasma during cold acclimation of rats] |
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| Y Xu,Z T Yang,C Z Su.Changes in beta-endorphin and its messenger RNA in pituitary, hypothalamus, lymphocytes and blood plasma during cold acclimation of rats][J].Acta Physiologica Sinica,1992,44(1):45-53. |
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| Authors: | Y Xu Z T Yang C Z Su |
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| Institution: | Molecular Biological Laboratory, 4th Military Medical University, Xi'an. |
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| Abstract: | Changes of beta-endorphin (beta-EP) and its mRNA in pituitary (P), hypothalamus (HT), lymphocytes (LC) and blood plasma (BP) during cold acclimation of SD male rats were studied by beta-EP mRNA dot blot, RP-HPLC and beta-EP radio-immunoassay (RIA). Experimental results showed: (1) After cold-exposure for 1 week pituitary beta-EP mRNA increased significantly with the appearance of stimulated cellular immune function. (2) beta-EP mRNA in hypothalamic immune center and peripheral LC increased when cold acclimation of animals was established for a cold exposure of 2 weeks (C2W). (3) From C2W onward, plasma beta-EP also continued to increase, indicating an augmented state of cellular immune function. As LC and plasma beta-EP product continued to show increase, pituitary beta-EP mRNA content recovered to control level from C2W onward possibly due to a feedback mechanism through LC-P-HT axis. |
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