Wound-healing studies in transgenic and knockout mice |
| |
Authors: | Richard Grose Sabine Werner |
| |
Institution: | (1) London Research Institute Lab 214, Cancer Research UK, 61 Lincoln’s Inn Fields, WC2A 3PX London;(2) Institute of Cell Biology, Department of Biology, ETH Zurich, 8093 Zurich, Switzerland |
| |
Abstract: | Injury to the skin initiates a cascade of events including inflammation, new tissue formation, and tissue remodeling, that
finally lead to at least partial reconstruction of the original tissue. Historically, animal models of repair have taught
us much about how this repair process is orchestrated and, over recent years, the use of genetically modified mice has helped
define the roles of many key molecules. Aside from conventional knockout technology, many ingenious approaches have been adopted,
allowing researchers to circumvent such problems as embryonic lethality, or to affect gene function in a tissue-or temporal-specific
manner. Together, these studies provide us with a growing source of information describing, to date, the in vivo function
of nearly 100 proteins in the context of wound repair.
This article focuses on the studies in which genetically modified mouse models have helped elucidate the roles that many soluble
mediators play during wound repair, encompassing the fibroblast growth factor (FGF) and transforming growth factor-β (TGF-β)
families and also data on cytokines and chemokines. Finally, we include a table summarizing all of the currently published
data in this rapidly growing field. For a regularly updated web archive of studies, we have constructed a Compendium of Published Wound Healing Studies on Genetically Modified Mice which is available at http://icbxs.ethz.ch/members/grose/woundtransgenic/home.html. |
| |
Keywords: | Would healing mouse gene targeting growth factor cytokine |
本文献已被 PubMed SpringerLink 等数据库收录! |
|