蛋氨酸羟基类似物对肉鸡抗氧化能力及代谢激素的影响

以雄性罗斯肉鸡为动物模型,探讨蛋氨酸(DLM)及其液体羟基类似物(HMTBA)对机体抗氧化能力及代谢激素水平的影响差异。结果显示,与对照以及DLM相比,饲粮添加HMTBA显著提高了肉鸡体增重、腿肌重、腿肌率、胸肌重(p<0.05);饲粮添加HMTBA能显著升高肉鸡血浆、肝脏以及肌肉组织的总抗氧化能力(T-AOC),提高还原型谷胱甘肽/氧化型谷胱甘肽的比率(GSH/GSSG)及增强抗氧化氢酶(CAT)活性(p<0.05);可显著降低全血自由基(ROS)含量和肝脏、肌肉组织中丙二醛(MDA)含量(p<0.05);饲粮添加0.24%的HMTBA显著增加了血浆T3、T4、FT3含量(p<0.05)。结果表明,HTMBA较DLM更能有效地改善机体氧化还原状态,增强抗氧化能力,进而调控代谢激素,提高机体游离甲状腺激素的水平,促进肉鸡生长和肌肉沉积。

Effects of Methionine and Methionine Hydroxy Analogue on Antioxidation and Metabolic Hormones of Broiler Chickens

In this experiment,different effects of 2-hydroxy-4-(methylthio) butanoic acid(HMTBA) and DL-methionine(DLM) on the redox state and metabolic hormone levels were determined in broilers.Compared with control,HMTBA-containing diet significantly improved body weight gain,breast weight,leg weight,and leg muscle rate(p<0.05).Additionally,a significant increase of T-AOC,GSH/GSSG,CAT levels in blood,muscle and liver tissue was found in HMTBA groups(p<0.05).And also,basal diet with HMTBA could significantly decrease the level of free radicals in whole blood and MDA in liver and muscle tissue(p<0.05).Furthermore,0.24% of HMTBA supplementation led to a significantly high levels of serum T3,T4 and FT3.Compared with DLM,HMTBA-containing diet could better restore redox status,improve the antioxidation,and then regulate metabolic hormones,improve the free thyroid hormone level,accelerate muscle deposition and growth in broilers.