Saccharomyces cerevisiae polymerase zeta functions in mitochondria |
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Authors: | Zhang Hengshan Chatterjee Aditi Singh Keshav K |
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Institution: | Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA. |
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Abstract: | The MtArg8 reversion assay, which measures point mutation in mtDNA, indicates that in budding yeast Saccharomyces cerevisiae, DNA polymerase zeta and Rev1 proteins participate in the mitochondrial DNA mutagenesis. Supporting this evidence, both polymerase zeta and Rev1p were found to be localized in the mitochondria. This is the first report demonstrating that the DNA polymerase zeta and Rev1 proteins function in the mitochondria. |
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