Immune cytolysis of human tumor cells mediated by xenogeneic "immune" RNA |
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| Authors: | L L Veltman D H Kern Y H Pilch |
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| Affiliation: | 1. Division of Oncology, Department of Surgery, University of California, Los Angeles 90024 U.S.A.;2. Tumor Immunology Laboratory, Veterans Administration Hospital, Sepulveda, California 91343 U.S.A. |
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| Abstract: | Normal, nonimmune, human peripheral blood lymphocytes, when incubated with RNA extracted from lymphoid organs of guinea pigs or sheep immunized with human tumor cells, mediated the immune cytolysis of those tumor cells in vitro. Lymphocytes incubated without RNA, or with control RNA preparations, failed to evidence cytotoxic activity. Treatment of the active RNA preparations with ribonuclease abrogated the cytotoxic activity, but treatment with deoxyribonuclease or pronase did not effect activity. |
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| Keywords: | Address reprint requests to Dr. Yosef H. Pilch. |
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