| 人脑原发性肿瘤癌基因扩增和重排的研究 |
| |
| 引用本文： | 颜铯,文一,孙芝琳,周锐先,廖文满.人脑原发性肿瘤癌基因扩增和重排的研究[J].中国生物化学与分子生物学报,1992,8(4):405-409. |
| |
| 作者姓名： | 颜铯 文一 孙芝琳 周锐先 廖文满 |
| |
| 作者单位： | 华西医科大学生物化学教研室生物化学与分子生物学研究所，华西医科大学生物化学教研室生物化学与分子生物学研究所，华西医科大学生物化学教研室生物化学与分子生物学研究所，华西医科大学神经外科教研室，华西医科大学神经外科教研室 成都 610041，成都 610041，成都 610041 |
| |
| 基金项目： | 国家科学基金，国家自然科学基金 |
| |
| 摘 要： | 作者对52例人脑原发性肿瘤和5例正常人脑DNA中c-myc、L-myc、Nmyc、erbB、c-fos、sis及Ha-ras等七种癌基因的扩增和重排进行了研究,发现多数胶质瘤中有c-myc、L-myc、erbB及c-fos等癌基因的扩增,少数胶质瘤和脑膜瘤中发现myc家族癌基因的限制性酶切区带位置有多态性变化;同时还观察到原发性脑瘤中存在两种或两种以上癌基因的扩增和重排现象。作者对癌基因与人脑原发性肿瘤的关系进行了讨论。
|
| 关 键 词： | 人脑肿瘤 癌基因 基因扩增 基因重排 |
| 收稿时间： | 1992-08-20 |
A Study of Amplification and Rearrangement of Oncogenes in Human Primary Brain Tumors |
| |
| Yan,Se Wen,Yi Sun,Zhi-lin Zhou,Rui-xian Liao,Wen-man.A Study of Amplification and Rearrangement of Oncogenes in Human Primary Brain Tumors[J].Chinese Journal of Biochemistry and Molecular Biology,1992,8(4):405-409. |
| |
| Authors: | Yan Se Wen Yi Sun Zhi-lin Zhou Rui-xian Liao Wen-man |
| |
| Institution: | (Dept of Biochemistry,Institute of Molecular Biology and Biochemistry,Dept of Neurosurgery,West China University of Medical Sciences,Chengdu 610041 |
| |
| Abstract: | The c-myc, L-myc, N-myc, erbB, c-fos, sis and Ha-ras oncogenes were used as probes to investigate the amplification and rearrangement of DNA isolated from 52 case of human primary brain tumors and 5 case of normal human brain by dot blot and Southern blot hybridization analysis.The results showed that the amplification of c-myc, L-myc, erbB and c-fos genes was usual in human brain glioma, and the alteration of myc gene family EcoRI fragments was in a few brain tumors.It slao showed that the amplification and rearrangement of two or two more oncogenes simultaneously in human primary brain tumor.The possible relationship between oncogenes and human brain tumor was discussed. |
| |
| Keywords: | Human brain tumor Oncogene Gene amplification Gene rerrangment |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《中国生物化学与分子生物学报》浏览原始摘要信息 |
| 点击此处可从《中国生物化学与分子生物学报》下载免费的PDF全文 |
|
