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Androgen receptor status predicts response to chemotherapy, not risk of breast cancer in Indian women |
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| Authors: | Chintamani Pranjal Kulshreshtha Anurupa Chakraborty LC Singh Ashwani K Mishra Dinesh Bhatnagar Sunita Saxena |
| Institution: | 1. Research fellow, Department of Obstetrics and Gynaecology, School of Graduate Medicine and Health, Royal Derby Hospital, Uttoxeter road, Derby, DE22 3DT, UK 2. Lecturer, Biological and Forensics Sciences, University of Derby, Keldeston road, Derby, DE22 1GB, UK 3. Professor and Head, Department of Obstetrics and Gynaecology, School of Graduate Medicine and Health, Royal Derby Hospital, Uttoxeter road, Derby, DE22 3DT, UK 4. Consultant Gynaecological Oncologist, Department of Obstetrics and Gynaecology, Royal Derby Hospital, Uttoxeter road, Derby, DE22 3NE, UK 5. Associate Professor, Department of Obstetrics and Gynaecology, School of Graduate Medicine and Health, Royal Derby Hospital, Uttoxeter road, Derby, DE22 3DT, UK |
| Abstract: | Voltage gated potassium channels have been extensively studied in relation to cancer. In this review, we will focus on the role of two potassium channels, Ether à-go-go (Eag), Human ether à-go-go related gene (HERG), in cancer and their potential therapeutic utility in the treatment of cancer. Eag and HERG are expressed in cancers of various organs and have been implicated in cell cycle progression and proliferation of cancer cells. Inhibition of these channels has been shown to reduce proliferation both in vitro and vivo studies identifying potassium channel modulators as putative inhibitors of tumour progression. Eag channels in view of their restricted expression in normal tissue may emerge as novel tumour biomarkers. |
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