| Abstract: | The aim of present study was to investigate the role of the X-ray repaircross-complementing protein1 (XRCC1) and Tumorprotein p53 (Tp53) polymorphisms in Uterine Leiomyoma(UL) susceptibility in southeastern Iran. This case control study was performed on139 women with UL and 149 age, BMI and ethnicity matched healthy women. All womenwere genotyped for the XRCC1 Arg399Gln, XRCC1Arg194Trp and Tp53 Arg72Pro polymorphisms. The frequency ofTp53 72 Pro/Pro genotype was significantly higher in UL womencompared to controls. The risk of UL was 1.5 fold higher in women with the Pro/Progenotype (OR, 1.5 [95% CI, 1.1 to 2.1], p = 0.012). Moreover, the frequency of thePro allele was significantly higher in the UL women. Although the frequency ofXRCC1 Arg399Gln genotypes did not significantly differ between ULand control groups before adjusting for age, there was an association between theXRCC1 Arg/Gln genotype and UL after adjusting for age (OR, 1.8[95% CI, 1.1 to 3]). No association was observed between the XRCC1Arg194Trp polymorphism and UL. The Pro/Pro genotype of Tp53 Arg72Propolymorphism was associated with UL susceptibility. In addition, theXRCC1 Arg/Gln genotype was associated with increased risk of ULafter adjusting for age. |
