Protective effects of Withania somnifera root on inflammatory markers and insulin resistance in fructose-fed rats |
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| Authors: | Zahra Samadi Noshahr Mohammad Reza Shahraki Hassan Ahmadvand Davood Nourabadi Alireza Nakhaei |
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| Institution: | 1. Department of Pharmacology, Zahedan University of Medical Sciences, Zahedan, Iran;2. Department of Physiology, Zahedan University of Medical Sciences, Zahedan, Iran;3. Department of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorram Abad, Iran;4. Department of Physiology, Iran University of Medical Sciences, Tehran, Iran |
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| Abstract: | Background:We investigated the effects of Withania somnifera root (WS) on insulin resistance, tumor necrosis factor α (TNF-α), and interleukin-6 (IL-6) in fructose-fed rats.Methods:Forty-eight Wistar-Albino male rats were randomly divided into four groups (n=12); Group I as control, Group II as sham-treated with WS by 62.5mg/g per diet, Group III fructose-fed rats received 10%W/V fructose, and Group IV fructose- and WS-fed rats. After eight weeks blood samples were collected to measure glucose, insulin, IL-6, and TNF-α levels in sera.Results:Blood glucose, insulin, homeostasis model assessment for insulin resistance (HOMA-R), IL-6, and TNF-α levels were all significantly greater in the fructose-fed rats than in the controls. Treatment with WS significantly (P < 0.05) inhibited the fructose-induced increases in glucose, insulin, HOMA-R, IL-6, and TNF-α.Conclusion:Our data suggest that WS normalizes hyperglycemia in fructose-fed rats by reducing inflammatory markers and improving insulin sensitivity.Key Words: Withania somnifera, Insulin resistance, IL-6, TNF- α |
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