Antipyretic doses of α-MSH do not alter afebrile body temperature in the cold期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

按检索

Antipyretic doses of α-MSH do not alter afebrile body temperature in the cold

Authors:	DB Richards JM Lipton

Institution:	1. Department of Anesthesiology, The University of Texas Health Science Center, 5323 Harry Hines Blvd, Dallas, TX 75235, U.S.A.;2. Department of Physiology, The University of Texas Health Science Center 5323 Harry Hines Blvd, Dallas, TX 75235, U.S.A.

Abstract:	1. 1.\|α-MSH (1/2–13) was injected centrally and peripherally in rabbits exposed to cold. 2. 2.\|Doses of the peptide previously shown to reduce fever had no effect on afebrile body temperature in the cold; larger doses did lower temperature. 3. 3.\|We conclude that the antipyretic effect of small doses of α-MSH does not depend upon inhibition of central heat productioin and heat conservatioin pathways. 4. 4.\|The antipyretic and hypthermic activities of α-MSH are independent and may represent different actions within the CNS. Keywords: α-MSH; antipyretic/hypothermogenic; fever; central temperature controls; cold exposure; rabbits

Keywords:	α -MSH antipyretic/hypothermogenic fever central temperature controls cold exposure rabbits
本文献已被 ScienceDirect 等数据库收录！