Contribution of Catalase and Superoxide Dismutase to the Intracellular Survival of Clinical Isolates of <Emphasis Type="Italic">Staphylococcus aureus</Emphasis> in Murine Macrophages |
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Authors: | Debaditya Das Biswadev Bishayi |
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Institution: | (1) Department of Physiology, Immunology Laboratory, University of Calcutta, 92, APC Road, Kolkata, 700009, West Bengal, India; |
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Abstract: | The present study was performed in order to carefully investigate the interaction of Staphylococcus aureus with murine macrophages and the contribution of catalase and superoxide dismutase in intracellular persistence of Staphylococcus aureus within murine macrophages during in vitro infection. We have reported that Staphylococcus aureus internalized by murine macrophages did not appear to be rapidly killed. Data indicating the contribution of a single catalase
and superoxide dismutase in intracellular survival of Staphylococcus aureus were provided using established biochemical assays. The results of the present experiment suggest that the survival of Staphylococcus aureus within phagocytic cells is facilitated by its ability to resist oxidative products. Organisms in the log phase of growth
clearly demonstrate a resistance to oxidative products. |
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Keywords: | Intracellular survival Staphylococcus aureus Murine macrophages Anti-oxidant enzymes |
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