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piggyBacis an effective tool for functional analysis of thePlasmodium falciparumgenome |
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| Authors: | Bharath Balu Chitra Chauhan Steven P Maher Douglas A Shoue Jessica C Kissinger Malcolm J Fraser John H Adams |
| Affiliation: | (1) Department of Global Health, 3720 Spectrum Blvd Suite 304, University of South Florida, Tampa, Florida 33612, USA;(2) Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA;(3) Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia 30602, USA;(4) Department of Genetics, University of Georgia, Athens, Georgia 30602, USA |
| Abstract: | BackgroundMuch of thePlasmodium falciparumgenome encodes hypothetical proteins with limited homology to other organisms. A lack of robust tools for genetic manipulation of the parasite limits functional analysis of these hypothetical proteins and other aspects of thePlasmodiumgenome. Transposon mutagenesis has been used widely to identify gene functions in many organisms and would be extremely valuable for functional analysis of thePlasmodiumgenome. |
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