| 抗生素耐药性的多重风险因子及针对性管控策略 |
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| 引用本文： | 周旸,张陆,王子华,钟江,王华.抗生素耐药性的多重风险因子及针对性管控策略[J].微生物学报,2018,58(11):2040-2050. |
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| 作者姓名： | 周旸 张陆 王子华 钟江 王华 |
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| 作者单位： | 复旦大学生命科学院, 上海 200433;俄亥俄州立大学食品科技系, 俄亥俄州 哥伦布市 43210,俄亥俄州立大学食品科技系, 俄亥俄州 哥伦布市 43210,俄亥俄州立大学食品科技系, 俄亥俄州 哥伦布市 43210,复旦大学生命科学院, 上海 200433,复旦大学生命科学院, 上海 200433;俄亥俄州立大学食品科技系, 俄亥俄州 哥伦布市 43210;俄亥俄州立大学微生物系, 俄亥俄州 哥伦布市 43210 |
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| 摘 要： | 抗生素耐药性已经对人类社会造成了重大影响，需要采取切实有效的管控措施，本文将针对耐药性研究领域的新视角，回顾了亟需重视的抗生素耐药性多重风险因素，包括非致病菌、食源和肠道菌群、粪便菌群、废水处理、用药途径和生物膜等，强调了口服抗生素的危害。通过总结针对性的耐药和疾病防控策略，为有效应对抗生素耐药性危机提供新思路。
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| 关 键 词： | 抗生素耐药性风险因子 耐药性管控 共生菌群 肠道菌群 给药途径 |
| 收稿时间： | 2018/7/31 0:00:00 |
| 修稿时间： | 2018/9/6 0:00:00 |
Key risk factors of antibiotic resistance ecology and targeted control strategies |
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| Yang Zhou,Lu Zhang,Zihua Wang,Jiang Zhong and Hua Wang.Key risk factors of antibiotic resistance ecology and targeted control strategies[J].Acta Microbiologica Sinica,2018,58(11):2040-2050. |
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| Authors: | Yang Zhou Lu Zhang Zihua Wang Jiang Zhong and Hua Wang |
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| Institution: | School of Life Sciences, Fudan University, Shanghai 200433, China;Department of Food Science and Technology, The Ohio State University, Columbus 43210, Ohio, USA,Department of Food Science and Technology, The Ohio State University, Columbus 43210, Ohio, USA,Department of Food Science and Technology, The Ohio State University, Columbus 43210, Ohio, USA,School of Life Sciences, Fudan University, Shanghai 200433, China and School of Life Sciences, Fudan University, Shanghai 200433, China;Department of Food Science and Technology, The Ohio State University, Columbus 43210, Ohio, USA;Department of Microbiology, the Ohio State University, Columbus 43210, Ohio, USA |
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| Abstract: | Antibiotic resistance has caused major damages to public health and social economy, and effective control has become a stressing need. This review summarizes recent changes in the scope and methods of antibiotic resistance investigation, and discusses the contributions of foodborne bacteria, gut, fecal and waste water microbiota, drug administration routes, and biofilm to the mega antibiotic resistance problem seen today. We also present new directions for mitigation of antibiotic resistance and diseases. |
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| Keywords: | antibiotic resistance risk factors antibiotic resistance mitigation commensal microbiota gut microbiota drug administration method |
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