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Renin-positive granulated Goormaghtigh cells |
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| Authors: | Dr J A Christensen A Bohle E Mikeler R Taugner |
| Institution: | (1) The Gade Institute, Department of Pathology, University of Bergen, Bergen, Norway;(2) The Institute of Pathology, University of Tübingen, Tübingen, Germany;(3) Institute of Physiology, University of Heidelberg, Heidelberg, Germany;(4) The Gade Institute, Department of Pathology, Haukeland University Hospital, N-5021 Bergen, Norway |
| Abstract: | Summary It is difficult to distinguish between Goormaghtigh cells (G-cells) and media cells of the glomerular arterioles at the border of the Goormaghtigh cell field. Consequently, it has been unclear whether renin-positive G-cells are normally present and also whether renin-producing cells are recruited from the pool of renin-negative G-cells upon stimulation of the renin-angiotensin system (RAS). In the present study, immunohistochemical and electron-microscopic experiments have been carried out on serially sectioned kidney biopsies from four patients with pseudo-Bartter syndrome. The results strongly suggest that with longlasting stimulation of the RAS all renin-negative ( secretory resting ) G-cells are ultimately converted into renin-producing granular cells.Synonymous with extraglomerular mesangial cells |
| Keywords: | Goormaghtigh cells Granular cells Renin synthesis Juxtaglomerular apparatus Pseudo-Bartter syndrome Human |
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