Lipid Peroxidation and Changes of Trace Elements in Mice Treated with Paradichlorobenzene |
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Authors: | Wang Suhua Lu Rongzhu Yin Changqing Xing Guangwei Han Fangan Jing Junjie Xu Wenrong Michael Aschner |
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Institution: | (1) Department of Preventive Medicine, School of Medical Science and Laboratory Medicine, Jiangsu University, 301 Xuefu Rd, Zhenjiang, Jiangsu, 212013, China;(2) Zhenjiang Environmental Monitoring Center, Zhenjiang, Jiangsu, 212002, China;(3) Zhenjiang Center for Disease Control and Prevention, Zhenjiang, Jiangsu, 212003, China;(4) Center of Chemical Analysis, School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, Jiangsu, 212013, China;(5) Department of Pediatrics, Pharmacology and Center for Molecular Neuroscience, Vanderbilt University Medical Center, Nashville, TN 37232, USA; |
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Abstract: | Paradichlorobenzene (pDCB) has been used as a space deodorant and moth repellant, as well as an intermediate in the chemical
industry. Given its broad applications and high volatility, considerable concern exists regarding the adverse health effects
of pDCB in the home and the workplace. In this study, changes in lipid peroxidation, antioxidants, and trace element levels
in the liver and kidney of pDCB-treated mice were investigated to determine their roles in toxicity. Mice were orally gavaged
once daily for seven consecutive days with pDCB (0 (corn oil control), 450, and 900 mg/kg). The level of malondialdehyde (MDA),
an end product of lipid peroxidation, markedly increased in the high-dose pDCB group in both the liver and kidney compared
with the control group. Changes in hepatic levels of reduced glutathione (GSH) in the pDCB groups were indistinguishable from
the control group, while renal levels of reduced GSH in the high-dose pDCB group were significantly lowered in comparison
to the control and the low-dose groups. Superoxide dismutase (SOD) activity in the liver of mice treated with pDCB showed
a downward trend, whereas there was no consistent trend associated with changes in SOD activity in the kidney. Additionally,
renal iron levels in the high-dose pDCB group were significantly decreased compared with the low-dose group and the controls,
whereas hepatic iron content in the low-dose pDCB group was significantly lower compared with the controls. Selenium and zinc
levels in the kidney were both significantly decreased in the high-dose pDCB group vs. the control and low-dose groups. There
were no treatment-induced changes in copper levels in either the kidney or liver. However, a significant increase was found
in the liver zinc/copper ratio in the high-dose pDCB group vs. the controls. In addition, blood zinc levels showed a downward
trend with increased pDCB dosage. These results suggest that pDCB toxicity is mediated by oxidative damage and tissue-specific
alterations in trace element levels both in the liver and the kidney of mice. |
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