Mechanical strain modulates age-related changes in the proliferation and differentiation of mouse adipose-derived stromal cells |
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| Authors: | See-Chang Huang Tzu-Chin Wu Hsiao-Chi Yu Mei-Ru Chen Chun-Min Liu Wen-Sheng Chiang Kurt M Lin |
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| Institution: | (1) Biomedical Engineering Research Laboratories, Industrial Technology Research Institute, Hsinchu, Taiwan;(2) Division of Medical Engineering Research, National Health Research Institutes, Zhunan Town, Miaoli, Taiwan;(3) Department of Biomedical Imaging and Radiological Sciences, National Yang Ming University, Taiwan |
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| Abstract: | Background Previous studies on the effects of aging in human and mouse mesenchymal stem cells suggest that a decline in the number and
differentiation potential of stem cells may contribute to aging and aging-related diseases. In this report, we used stromal
cells isolated from adipose tissue (ADSCs) of young (8-10 weeks), adult (5 months), and old (21 months) mice to test the hypothesis
that mechanical loading modifies aging-related changes in the self-renewal and osteogenic and adipogenic differentiation potential
of these cells. |
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