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| 氟苯尼考琥珀酸钠抗菌活性研究 | |
| 引用本文： | 秦光成,李逐波,张聪,刘畅,杨鹏,陈力学.氟苯尼考琥珀酸钠抗菌活性研究[J].微生物学杂志,2011,31(2):54-58. |
| 作者姓名： | 秦光成 李逐波 张聪 刘畅 杨鹏 陈力学 |
| 作者单位： | 1. 重庆医科大学附属第一医院,实验研究中心,重庆,400016 2. 西南大学,药学院,重庆,400716 3. 第三军医大学,动物中心,重庆,400038 |
| 基金项目： | 重庆市科技攻关计划项目 |
| 摘 要： | 研究氟苯尼考琥珀酸钠在体内转化后的抗菌效果,为临床前给药提供一定的理论依据。用微生物法,以抑菌圈直径为指标,考察氟苯尼考琥珀酸钠（前药）转化后对敏感菌的抗菌活性。给大鼠按30 mg/kg肌注前药1 h后,可以达到最大血药浓度4.0μg/mL,与氟苯尼考（母药）的抗菌活性相当。氟苯尼考琥珀酸钠在大鼠体内能够迅速转化为母药而发挥其抗菌活性。 |
| 关 键 词： | 氟苯尼考琥珀酸钠 抗菌 抑菌圈 |
Antibacterial Activity of Florfenicol Sodium Succinate |
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| QIN Guang-cheng,LI Zhu-bo,ZHANG Cong,LIU Chang,YANG Peng,CHEN Li-xue.Antibacterial Activity of Florfenicol Sodium Succinate[J].Journal of Microbiology,2011,31(2):54-58. | |
| Authors: | QIN Guang-cheng LI Zhu-bo ZHANG Cong LIU Chang YANG Peng CHEN Li-xue |
| Institution: | QIN Guang-cheng 1,LI Zhu-bo2,ZHANG Cong3,LIU Chang2,YANG Peng2,CHEN Li-xue1(1.Lab.Res.Ctr.,The First Affil.Hosp.,Chongqing Med.Uni.,Chongqing 400016,2.Coll.of Pharm.Sci.,SW Uni.,Chongqing,Beibei 400716,3.Lab.Anim.Ctr.Third Mil.Med.Uni.Chongqing 400038) |
| Abstract: | Antibacterial effects of florfenicol sodium succinate(F-S-Na) in vivo conversion was studied to provide a certain theoretical basis for potential preclinical administration.Diameter of inhibitory ring of microbiological method was used as an index to observe the antibacterial activity of F-S-Na(produg) after being converted.The results showed that Cmax of hemato-medicine was 4.0 μg/mL 1 h after i.m administration according to 30 mg/kg,and its antibacterial activity was about the same as florfenicol.Therefore F-S-Na could be rapidly converted to parent medicine and give scope to its antibacterial activity. |
| Keywords: | florfenicol sodium succinate antibacterial inhibition ring |
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