High level secretory expression of murine OCIL by CHO cells and action of OCIL on osteoclast differentiation |
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| Authors: | Zhuang Cui Meng Mi Jun Wang Hui Liang Fang Zheng Bao-Li Wang Xiao-Xia Li |
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| Institution: | 1.College of Public Health,Tianjin Medical University,Tianjin,PR China;2.Department of Orthopaedics, Xiangya Hospital,Central South University,Changsha, Human Province,PR China;3.Key Lab of Ministry of Health for Hormone and Development,Tianjin Medical University Institute of Endocrinology,Tianjin,PR China;4.College of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin,PR China;5.Tianjin Medical University School of Basic Science,Tianjin,PR China |
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| Abstract: | Receptor activator of nuclear factor-kB ligand (RANKL), a well-known membrane-bound molecule expressed on osteoblasts and
bone marrow stromal cells, is believed to induce osteoclast differentiation and activation by binding to the receptor activator
of nuclear factor-kB (RANK), which is expressed on the surface of osteoclast lineage cells. This induction is inhibited by
osteoprotegerin (OPG) that is secreted by osteoblast lineage and acts as a decoy receptor of RANKL. Currently the essential
role of the OPG/RANKL/RANK system in the process of osteoclast maturation, as well as activation, has been well established,
and the majority of bone resorption regulators control osteoclast formation and activation through their effects on this system
and especially on the relative expression levels of RANKL and OPG 1]. |
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