"Threading" of beta-sheet peptides via radical polymerization |
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| Authors: | Mori Takeshi Yasutake Shiro Inoue Hideki Minagawa Keiji Tanaka Masami Niidome Takuro Katayama Yoshiki |
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| Affiliation: | Department of Applied Chemistry and Center for Future Chemistry, Kyushu University, 744 Motooka Nishi-ku, Fukuoka 819-0395, Japan. moritcm@mbox.nc.kyushu-u.ac.jp |
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| Abstract: | A nonamer peptide containing a diene group in the center of the sequence was synthesized. When the peptide forms an antiparallel beta-sheet, the diene groups align ca. 5 A apart on the beta-sheet. The diene groups successfully photopolymerized without distorting the beta-sheet structure. The obtained beta-sheet showed high stability against acid denaturation and addition of 1,1,1,3,3,3-hexafluoroisopropanol. |
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