The fine structure of HNK-1 (Leu7) positive cells |
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| Authors: | G. C. Manara G. De Panfilis C. Ferrari A. Bonati R. Scandroglio |
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| Affiliation: | (1) Istituto di Istologia ed Embriologia Generale, University of Parma, Italy;(2) Dermatologia Sperimentale, University of Parma, Italy;(3) Istituto di Anatomia ed Istologia Patologica, University of Parma, Italy;(4) Istituto di Patologia Speciale Medica, University of Parma, Italy;(5) Istituto di Istologia ed Embriologia Generale, Ospedale Maggiore, Via Gramsci, 14, I-43100 Parma PR, Italia |
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| Abstract: | ![]()
Summary The ultrastructural characteristics of HNK-1 (Leu7) positive cells, visualized with a peroxidase labelled anti-mouse IgM serum, were analysed. Our investigation demonstrates: 1) the majority of Leu7 positive cells has a low nuclear/cytoplasmic ratio (N/C), an irregular outline, a well developed smooth endoplasmic reticulum, parallel tubular arrays (PTA) and electron dense granules; 2) the minority of Leu7 positive cells has a high N/C, regular profiles and lacks electron dense granules. The presence of two distinct ultrastructural patterns within Leu7 positive cells may represent: 1) the expression of subsequent stages of cell differentiation; 2) two distinct Leu7 positive cell subpopulations. |
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