Epidemiological and genetic study of 200 cases of oral cleft in the Emilia Romagna region of northern Italy |
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| Authors: | E Calzolari M Milan G B Cavazzuti G Cocchi E Gandini C Magnani M Moretti G P Garani G P Salvioli S Volpato |
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| Institution: | Istituto di Genetica Medica, Università Ferrara, Italy. |
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| Abstract: | Epidemiological and genetic variables in clefts were analyzed during the years 1978-1986 in a case-control study of congenital malformations in the Emilia Romagna region of northern Italy. Among 150,168 newborns, 200 cases of cleft were detected, yielding a prevalence of 1.33 per 1,000. These clefts consisted of 112 (0.075%) cases of cleft lip with or without cleft palate (CL +/- P) and 88 cases (0.058%) of cleft palate (CP). Coexisting abnormalities were found in 32% of cases. The heritability coefficient of CL +/- P was 0.84. No cluster in time or space could be demonstrated. Epilepsy was the only maternal risk factor found to be correlated with clefts. A predominance of males was found among CL +/- P cases. |
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