Histochemical study on the localization of glucose-6-phosphate dehydrogenase induced by androgen or thyroxine in the convoluted tubules of mouse submandibular gland |
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| Authors: | Y Tajima N Utsumi T Takuma M Kumegawa |
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| Institution: | (1) Department of Oral Pathology, Josai Dental University, 350-02 Sakado, Saitama, Japan;(2) 1st Department of Oral Anatomy, Josai Dental University, 350-02 Sakado, Saitama, Japan |
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| Abstract: | Summary The effects of 5 -dihydrotestosterone (DHT) and thyroxine (T4) on glucose-6-phosphate dehydrogenase (G-6-PDH) activity in mouse submandibular gland were investigated histochemically. A strong positive histochemical reaction for G-6-PDH was observed in the excretory ducts of untreated male and female mice, with a slight reaction in the basal portion of the convoluted tubules (striated ducts) of males. Administraition of DHT to female mice increased G-6-PDH activity specifically in the convoluted tubules. T4 increased the enzyme activity in the tubules more than DHT. The induction of G-6-PDH activity by T4 in adrenalectomized mice suggests that T4 has a direct effect on the submandibular gland. |
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