| 鸡MyD88-TIR的同源模建 |
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| 引用本文： | 赵兴旺,刘冉冉,郑麦青,文杰,陈继兰,赵桂苹.鸡MyD88-TIR的同源模建[J].生物信息学,2011,9(4):331-334,338. |
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| 作者姓名： | 赵兴旺 刘冉冉 郑麦青 文杰 陈继兰 赵桂苹 |
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| 作者单位： | 中国农业科学院北京畜牧兽医研究所,北京,100193 |
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| 基金项目： | 国家自然科学基金，现代农业产业技术体系建设专项资金 |
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| 摘 要： | 髓样分化因子(MyD88)是Toll受体(TLR)信号通路中的一个关键接头分子,在传递信息和介导炎症反应中具有重要的作用。对鸡MyD88(Myeloid differentiation primary response protein MyD88)的TIR(Toll-interleukin1-resistance)区域进行同源建模,并评估其可用性,为进一步研究MyD88与TLR(Toll receptor)相互作用的原理奠定基础。通过结构域分析、模板相似性搜索和序列比对、初始建模、精修和动力学优化,立体化学结构和能量合理性评估,获得未知三维结构的鸡MyD88-TIR三维模型。结果表明,鸡MyD88包含DEATH和TIR两个结构域,所模拟的MyD88-TIR三维模型二面角构象和氨基酸能量分布以及主侧链立体化学特性合理。
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| 关 键 词： | 鸡 MyD88-TIR 同源建模 合理性评估 |
Homology modeling of the chicken MyD88 -TIR |
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| ZHAO Xing-wang,LIU Ran-ran,ZHENG Mai-qing,WEN jie,CHEN Ji-lan,ZHAO Gui-ping.Homology modeling of the chicken MyD88 -TIR[J].China Journal of Bioinformation,2011,9(4):331-334,338. |
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| Authors: | ZHAO Xing-wang LIU Ran-ran ZHENG Mai-qing WEN jie CHEN Ji-lan ZHAO Gui-ping |
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| Institution: | ZHAO Xing-wang,LIU Ran-ran,ZHENG Mai-qing,WEN jie,CHEN Ji-lan,ZHAO Gui-ping (Institute of Animal Sciences,Chinese Academy of Agricultural Sciences,Beijing 100193,China) |
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| Abstract: | Myeloid differentiation primary response protein 88(MyD88) is a key factor in Toll-like receptor (TLR) signaling passway and is of great importance in information transfering and inflammatory response.This study was conducted to generate an ideal three-dimensional structural model of the TIR(Toll-interleukin 1-resistance)domain of MyD88(Myeloid differentiation primary response protein).The homology modeling procedure included four sequential steps:1)Identification and analysis of the domain architectures;2)... |
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| Keywords: | chicken MyD88-TIR homology modeling evaluation of model |
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