COPD患者C反应蛋白、TNF-α、IL-8、IL-6临床研究

目的：探讨血清中C反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）、白介素-8（IL-8）、白介素-6（IL-6）的水平变化在慢性阻塞性肺疾病（COPD）的发生发展中的作用及临床意义。方法：采用酶联免疫吸附法及全自动生化仪对35例COPD患者急性发病期和缓解期血清中的CRP、TNF-α、IL-8和IL-6浓度进行检测。结果：①COPD缓解期CRP、TNF-α、IL-8和IL-6含量显著低于急性期,但仍高于对照组（P〈0.05）。②吸烟因素可增加COPD患者血清中CRP、TNF-α、IL-8和IL-6含量。③血清中CRP、TNF-α、IL-8和IL-6含量与肺功能指标FEV1%和FEV1/FVC%呈负相关。结论：CRP、TNF-α、IL-8和IL-6参与了COPD患者气道炎症反应,可能与疾病的严重程度有关,可作为判断预后的辅助指标;吸烟可能是COPD发生发展的重要因素。

Effect of CRP,TNF-α,IL-8 and IL-6 in Patients with Chronic Obstructive Pulmonary Disease

Objective：To investigate the effect and clinical significance of serum levels of CRP,TNF-α,IL-8 and IL-6 in COPD.Methods：The concentrations of serum TNF-α,IL-8 and IL-6 were measured by ELISA.The level of CRP in plasma was also tested.Results：① The levels of CRP,TNF-α,IL-8 and IL-6 significantly decreased in AECOPD,but sill significantly higher than SCOPD（P0.05）.② Smoking significantly increased the serum levels of CRP,TNF-α,IL-8 and IL-6.③ Serum levels of CRP,TNF-α,IL-8 and IL-6 were inversely correlated with FEV1% and FEV1/FVC%.Conclusion：CRP,TNF-α,IL-8 and IL-6 may be involved in the chronic airway inflammatory process in COPD,and correlate with the severity.And they may predict the prognosis of COPD patients.Smoking may play important role in the development of COPD.