| 早期负性经历的表观遗传学研究进展 |
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| 引用本文： | 姚亚丽,李昌琪.早期负性经历的表观遗传学研究进展[J].生物磁学,2011(1):161-164. |
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| 作者姓名： | 姚亚丽 李昌琪 |
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| 作者单位： | 中南大学湘雅医学院人体解剖与神经生物学系,湖南长沙410013 |
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| 基金项目： | 国家自然科学基金项目（302001098） |
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| 摘 要： | 表观遗传学（epigenetics）是指不涉及DNA序列改变、可以通过有丝分裂和减数分裂进行遗传的基因表达变化的遗传学分支领域。目前研究主要集中在DNA甲基化、组蛋白密码、染色质重塑和非编码RNA调控等方面。早期负性经历是指个体出生早年所经历的不良生活事件,还包括个体出生前所经历的负性生活事件。大量研究表明早期负性经历对个体成年后的行为会造成明显影响。本文将综述早期负性经历中表观遗传的各种机制。
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| 关 键 词： | 负性经历 表观遗传 个体行为 |
The Progress of Epigenetics in Early Adverse Experiences |
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| YAO Ya-li,LI Chang-qi.The Progress of Epigenetics in Early Adverse Experiences[J].Biomagnetism,2011(1):161-164. |
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| Authors: | YAO Ya-li LI Chang-qi |
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| Institution: | △(Department of Anatomy and Neurobiology,Xiang-ya Medical College,Central South University,changsha,410013) |
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| Abstract: | Epigenetics is a branch of genetics,with no changes of DNA sequence,the genetic expression changes are through mitosis and meiosis.Current researches are focused on DNA methylation,histone code,chromatin remodeling and regulation of non-coding RNA and so on.Early adverse experiences points to negative life events experienced by an individual in the early years after born,it also includes before born.Numerous studies show that Early adverse experiences will affect the adult behaviors of individuals.This paper will survey all kinds of epigenetic mechanisms in the early negative experiences. |
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| Keywords: | Adverse experience Epigenetics Individual behavior |
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