| 志贺毒素及其预防治疗剂的研究进展 |
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| 引用本文： | 刘越男,李珊珊,董秀,谷丽维,李建春.志贺毒素及其预防治疗剂的研究进展[J].生物磁学,2011(2):397-400. |
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| 作者姓名： | 刘越男 李珊珊 董秀 谷丽维 李建春 |
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| 作者单位： | 沈阳药科大学,辽宁沈阳110016 |
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| 摘 要： | 志贺毒素（Shigatoxin,Stx）主要由肠出血性大肠杆菌（EHEC）产生,是其主要的致病毒力因子,可通过引起急性肾衰竭导致死亡。迄今为止尚没有可推荐的治疗方案能够有效地预防或治疗Stx引起的疾病。目前,对于Stx的研究热点主要包括：Stx尚未清楚的致病机理研究,Stx与HUS的相关性研究,以及预防、治疗由Stx引起的疾病的研究。本文就以上几方面对国内外的相关研究进行总结及讨论。
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| 关 键 词： | 志贺毒素 溶血性尿毒综合征 产志贺毒素大肠杆菌 |
The development of study on Shiga toxin and the prevention and treatment |
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| LIU YUE-nan,LI Shan-shan,DONG Xiu,GU Li-wei,LI Jian-Chun.The development of study on Shiga toxin and the prevention and treatment[J].Biomagnetism,2011(2):397-400. |
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| Authors: | LIU YUE-nan LI Shan-shan DONG Xiu GU Li-wei LI Jian-Chun |
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| Institution: | (Shenyang Pharmaceutical University,Shenyang,Liaoning,110016,PR China) |
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| Abstract: | Stx is a member of the family of protein toxins produced by Escherichia coli O157：H7 and other enterohaemorrhagic E.coli.Renal disease was thought to be due to the combined action of Shiga toxin,which was the primary virulence factor of Shiga toxin.So far,there is no effective treatment of Stx-complications.Nowadays,the focus on Stx including：the unknown nosogenesis of Stx,the relationship between Stx and HUS,and prevention and treatment of Stx-complications.This paper will give a reviewe on important aspects of Stx. |
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| Keywords: | Shiga toxin HUS STEC |
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