Mean arterial pressure nonlinearity in an elastic circulatory system subjected to different hematocrits |
| |
Authors: | Branigan Tom Bolster Diogo Vázquez Beatriz Y Salazar Intaglietta Marcos Tartakovsky Daniel M |
| |
Institution: | (1) Department of Pediatrics and Cardiovascular Research Institute, University of California, 505 Parnassus Avenue, San Francisco, CA 94143, USA;(2) 925 Tiburon Boulevard, Tiburon, CA 94920-1525, USA |
| |
Abstract: | The level of hematocrit (Hct) is known to affect mean arterial pressure (MAP) by influencing blood viscosity. In the healthy
population, an increase in Hct (and corresponding increase in viscosity) tends to raise MAP. However, data from a clinical
study of type 2 diabetic patients indicate that this relationship is not universal. Instead, individuals in the lower levels
of Hct range display a decrease in MAP for a given rise in Hct. After reaching a minimum, this trend is reversed, so that
further increases in Hct lead to increases in MAP. We hypothesize that this anomalous behavior occurs due to changes in the
circulatory autoregulation mechanism. To substantiate this hypothesis, we develop a physically based mathematical model that
incorporates autoregulation mechanisms. Our model replicates the anomalous U-shaped relationship between MAP and Hct found
in diabetic patients in the same range of Hct variability. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|