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Discovery of 5-HT6 receptor ligands based on virtual HTS |
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| Authors: | Tasler Stefan Kraus Jürgen Wuzik Andreas Müller Oliver Aschenbrenner Andrea Cubero Elena Pascual Rosalia Quintana-Ruiz Jordi-Ramon Dordal Alberto Mercè Ramon Codony Xavier |
| Affiliation: | 4SC AG, Am Klopferspitz 19a, 82152 Planegg-Martinsried, Germany. stefan.tasler@4sc.com |
| Abstract: | Based on a pharmacophore alignment on a 5-HT(6) ligand applying 4SCan technology, a new lead series was identified and further structurally investigated. K(i)s down to 8 nM were achieved. |
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