TOR signaling: an odyssey from cellular stress to the cell growth machinery |
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| Authors: | Abraham Robert T |
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| Affiliation: | Signal Transduction Program, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA. abraham@burnham.org |
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| Abstract: | 
The target of rapamycin (TOR) protein kinase is centrally involved in the coordination of cell growth and proliferation with the availability of growth factors and nutrients. Two recent reports have illuminated a mechanism whereby hypoxic stress dampens TOR signaling in metazoan cells. |
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