|
|||||
|
|
Role of endogenous cyclo(His-Pro) in cold-induced hypothermia in the desert rat (Mastomys natalensis) |
|
| Authors: | Rakesh Shukla N.H. Rahmani Haruo Mizuma Rikhab Chand Srimal Chandan Prasad |
| Affiliation: | a Division of Pharmacology, Central Drug Research Institute, Lucknow, India b Section of Endocrinology, Department of Medicine, Obesity Research Program, Louisiana State University Medical Center, New Orleans, LA 70112, USA |
| Abstract: | Central administration of exogenous cyclo(His-Pro) (CHP) is known to produce hypothermia in rodents. In the present study, we examined the role of endogenous CHP in cold-induced hypothermia in the desert rat, Mastomys natalensis. The results of these studies show that a rise in hypothalamic CHP content accompanied a decrease in rectal temperature during cold exposure. Immunoneutralization of endogenous CHP resulted in a significant decline in cold-induced hypothermia. In addition, central administration of cyclo(Ala-Gly), a structural analogue of CHP, also led to a decrease in cold-induced hypothermia. The results of these studies show that changes in endogenous CHP levels may affect body temperature regulation. |
| Keywords: | Mastomys natalensis Cyclo(His-Pro) Hypothermia Thermoregulation Cold-induced hypothermia Endogenous cyclo(His-Pro) Cyclo(Ala-Gly) |
| 本文献已被 ScienceDirect 等数据库收录！ | |