| 肿瘤化疗与药物代谢酶 |
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| 作者姓名： | Xu F Zhen YS Shao RG |
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| 作者单位： | 1. 南方医科大学珠江医院,广州,510280
2. 中国医学科学院医药生物技术研究所,北京,100050 |
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| 基金项目： | 国家重点基础研究计划项目(973)(2002CB513108),广东医学科研基金(A2003471)资助课题 |
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| 摘 要： | 药物代谢酶(DME)在药物代谢解毒和药物代谢活化中起着重要的作用,对组织器官的药物效应和毒性的易感性产生重要影响。DME在肿瘤组织和非肿瘤组织表达和活性存在差异。与常用化疗药物有关的药物代谢酶主要有细胞色素P450(CYP)、谷胱甘肽S-转移酶(GST)、尿苷二磷酸-葡萄糖醛酸转移酶(UGT)、巯嘌呤甲基转移酶(TPMT)和二氢嘧啶脱氢酶(DPD),这些酶均具有遗传多态性,在一定条件下可以被诱导,具有个体差异。
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| 关 键 词： | 肿瘤组织 药物代谢 药物代谢酶 |
Cancer chemotherapy and drug metabolism enzyme |
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| Xu F,Zhen YS,Shao RG.Cancer chemotherapy and drug metabolism enzyme[J].Progress in Physiological Sciences,2005,36(4):295-298. |
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| Authors: | Xu Feng Zhen Yong-Su Shao Rong-Guang |
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| Institution: | Zhujiang Hospital, Southern Medical University, Guangzhou 510280; Institute of Medicihal Biotechnology, Chinese Academy of Medical Sciences, Beijing 100050 |
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| Abstract: | Drug metabolism enzymes(DME) play a significant role in drug detoxification and activation,which exert important effect on drug efficacy and sensitivity to toxicity.There is difference in expression and activity of DME between in tumor tissue and in non-tumor tissue.DME related with tumor chemotherapy are cytochrome P450(CYP),glutathione-S-transferase(GST),uridine diphospho-glucuronosyltransferase(UGT),thiopurine methyltransferase(TPMT) and dihydropyrimidine dehydrogenase(DPD).The enzymes above are inducible and genetic polymorphic,thus with variable activity in individuals. |
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| Keywords: | Tumor tissue Drug metabolism Drug metabolism enzyme |
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