Evaluation of anti-inflammatory activity of Alstonia macrophylla Wall ex A. DC. leaf extract. |
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| Authors: | G Arunachalam D Chattopadhyay S Chatterjee A B Mandal T K Sur S C Mandal |
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| Institution: | ICMR Virus Unit Calcutta, I.D. & B.G. Hospital, Beliaghata, Kolkata, India. |
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| Abstract: | Methanolic extract of dried leaves of Alstonia macrophylla Wall ex A. DC. and its fractions were investigated for its anti-inflammatory activity. The extract at a concentration of 200 mg kg(-1) and 400 mg kg(-1), p.o. and its fractions at 25 mg kg(-1) and 50 mg kg(-1), p.o. showed the significant dose dependent antiinflammatory activity in carrageenan and dextran-induced rats hind paw edema (acute models) as well as in cotton pellet-induced granuloma (chronic model) in rats. Anti-inflammatory activity of the tested extract and its fractions was comparable with that of the standard drug Indomethacin (10 mg kg(-1)). |
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