| 禽流感的哺乳类动物模型研究进展 |
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| 引用本文： | 邓少嫦,张钰,黄韧. 禽流感的哺乳类动物模型研究进展[J]. 中国实验动物学杂志, 2009, 0(12): 40-43,75 |
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| 作者姓名： | 邓少嫦 张钰 黄韧 |
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| 作者单位： | [1]广州中医药大学附属南海妇产儿童医院,广东佛山528200 [2]广东省实验动物监测所,广东广州510260 |
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| 基金项目： | 广东省自然科学基金（06023011）;广东省科技计划（2005B20201019）;广东省重点实验室建设（2007A060101002）. |
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| 摘 要： | N1禽流感为新的人畜共患性疾病，建立良好的哺乳动物模型是进一步深入研究人禽流感防治的重要基础。本文报道了禽流感哺乳动物模型研究进展，对病原株、造模方法、模型的临床特征、病理变化、病毒复制等方面进行归纳，比较了小鼠模型、雪貂模型和非人灵长类动物模型特点。各种禽流感动物模型有各自的优点和缺点，应根据不同的实验目的和实验条件选择合适的病毒株和实验动物进行造模。
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| 关 键 词： | H5N1禽流感病毒 模型 动物 哺乳类 |
Advances in Research on Animal Models for H5N1 Avian Influenza |
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| DENG Shao-Chang,ZHANG Yu,HUANG Ren. Advances in Research on Animal Models for H5N1 Avian Influenza[J]. Chinese Journal of Laboratory Animal Science, 2009, 0(12): 40-43,75 |
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| Authors: | DENG Shao-Chang ZHANG Yu HUANG Ren |
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| Affiliation: | 1. Nanhai Affiliated Maternity and Child Care Hospital of Guangzhou University of Traditional Chinese Medicine,Foshan 528200, China ; 2. Guangdong Laboratory Animal Monitoring Institute, Guangzhou 510260, China) |
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| Abstract: | The outbreaks of H5N1 avian influenza in humans have stressed the need for animal models of avian influenza for further study. Mice,ferrets and nonhuman primate models for H5N1 avian influenza are introduced in this paper,and issues on the virus, methods, clinical characteristics, pathology, virus replication, advantage and disadvantage of the models are explored. Proper avian virus and animal models should be selected according to different research objectives and experiment conditions. |
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| Keywords: | H5N1 avian influenza virus Animal models Mammals |
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