| 神经生长因子与神经系统老化 |
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| 引用本文： | 王蓉,李林.神经生长因子与神经系统老化[J].中国实验动物学杂志,2009(4):63-66. |
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| 作者姓名： | 王蓉 李林 |
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| 作者单位： | 首都医科大学宣武医院教育部神经变性病重点实验室,北京100053 |
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| 基金项目： | 国家重点基础研究计划.973计划项目（2003CB517104）;国家自然科学基金（30772288）,北京市自然科学基金（7082043）. |
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| 摘 要： | 老化通常指生物体生长发育成熟以后,随年龄增加生理机能逐渐减退,内环境稳定性下降,组织器官逐渐发生退行性改变,最终走向衰老、死亡的过程。神经系统老化是神经元退行性病变形成的基础和条件。由于神经生长因子（nerve growth factor,NGF）与中枢神经系统胆碱能神经元的存活和可塑性调节密切相关,所以NGF在神经系统老化和神经退行性变疾病如老年性痴呆（Alzheimer’s disease,AD）的发生发展过程中发挥重要作用。本文综述了NGF在脑老化中的变化及其与AD发病机制的关系。
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| 关 键 词： | 神经生长因子 神经系统老化 老年性痴呆 |
Nerve Growth Factor and Aging of the Nervous System |
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| WANG Rong,LI Lin.Nerve Growth Factor and Aging of the Nervous System[J].Chinese Journal of Laboratory Animal Science,2009(4):63-66. |
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| Authors: | WANG Rong LI Lin |
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| Institution: | (Key laboratory for Neurodegenerative Diseases of Ministry of Education, Xuanwu Hospital of Capital Medical University, Beijing 100053, China) |
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| Abstract: | Aging usually refers to the physiological function reduced with age-increasing after the growth and development of a mature organism, internal environmental instability, tissues and organs undergoing gradually degeneration, and ultimately changing towards aging. Nervous system aging is the foundation and conditions of neuro-degenerative diseases. Nerve growth factor （NGF） and eholinergic neurons in central nervous system survival and plasticity are closely related to regulation, so NGF plays an important role in the nervous system aging and development of nem＇o-degenerative diseases such as Alzheimer＇s disease （AD）. In this paper, we review the changes of NGF during brain aging and its relationship between the pathogenesis of AD. |
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| Keywords: | Nerve growth factor Nervous system aging Alzheimer＇s disease |
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