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A novel splice variant of the human dicer gene is expressed in neuroblastoma cells
Authors:Nicoletta Potenza  Paola Scaruffi  Gian Paolo Tonini
Affiliation:a Department of Life Sciences, Second University of Naples, Via Vivaldi 43, 81100 Caserta, Italy
b Translational Paediatric Oncology, National Cancer Research Institute (IST), Largo R. Benzi 10, Genoa 16132, Italy
Abstract:Dicer is a ribonuclease playing a key role in the biogenesis of microRNAs and small interfering RNAs. Here we report the identification of a novel splice variant of human dicer gene, the first one bearing a modified coding sequence. It encodes a truncated protein, t-Dicer that lacks the dsRNA-binding domain and is defective in one of the two RNase III catalytic centers. The splice variant was found in neuroblastoma cells and in cells induced to neuronal differentiation, whereas it was not detectable in other cell lines or in normal tissues. Interestingly, it occurred in primary neuroblastic tumors, mainly in stroma poor neuroblastomas.
Keywords:Dicer   miRNA   Neuroblastoma   Neural differentiation   RNase   Alternative splicing
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