Inhibition of HIV-1 nuclear import via schiff base formation with arylene bis(methylketone) compounds |
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| Authors: | Al-Abed Yousef Dubrovsky Larisa Ruzsicska Bela Seepersaud Mohindra Bukrinsky Michael |
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| Affiliation: | Laboratory of Medicinal Chemistry, North Shore-LIJ Research Institute, 350 Community Drive, Manhasset, NY, 11030, USA. yalabed@nshs.edu |
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| Abstract: | ![]()
Arylene bis(methylketone) compounds specifically block nuclear translocation of the HIV-1 pre-integration complex by forming Schiff-base adducts with contiguous lysines within nuclear localization signal. |
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