Searching for a successful HDL-based treatment strategy |
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| Authors: | Srinivasa T. Reddy Mohamad Navab G.M. Anantharamaiah Alan M. Fogelman |
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| Affiliation: | 1. Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA;2. Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA;3. Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA;4. Department of Medicine, University of Alabama at Birmingham, AL 35294, USA |
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| Abstract: | Despite strong evidence that HDL-cholesterol levels predict atherosclerotic events in a population, attempts at using an HDL-based treatment strategy have not yet been successful. Most of the efforts to date have focused on raising plasma HDL-cholesterol levels. This brief review focuses on a different strategy, which is based on the use of 18-amino acid apoA-I mimetic peptides. The story of these peptides spans decades and illustrates the remarkable complexity of HDL-based treatment strategies, but suggests that such a strategy may still be successful. |
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| Keywords: | ApoA-I, apolipoprotein A-I CHD, coronary heart disease EV, transgenic tomatoes constructed with an empty vector FGF, Fibroblast Growth Factor FGFR1, FGF Receptor 1 FPLC, fast performance liquid chromatography HDL, high density lipoprotein HIF-1α, hypoxia-inducible factor-1α LDL, low density lipoprotein LDLR&minus /&minus , LDL receptor null LPA, lysophosphatidic acid MCP-1, Monocyte chemoattractant protein 1 MnSOD, manganese superoxide dismutase SQ, subcutaneous injection SR-A, scavenger receptor A Tg6F, transgenic 6F tomatoes TLR, toll-like receptor VEGF, Vascular Endothelial Growth Factor VEGFR2, VEGF Receptor 2 WD, Western diet |
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