The Use of Phase Inversion Temperature (PIT) Microemulsion Technology to Enhance Oil Utilisation during Streptomyces rimosus Fed-batch Fermentations to Produce Oxytetracycline |
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| Authors: | Panos?A.?Papapanagiotou,Henry?Quinn,Jean-Pierre?Molitor,Alvin?W.?Nienow,Christopher?J.?Hewitt mailto:c.j.hewitt@bham.ac.uk" title=" c.j.hewitt@bham.ac.uk" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author |
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| Affiliation: | (1) Biochemical Engineering, Department of Chemical Engineering, The University of Birmingham, B15 2TT Edgbaston, Birmingham, UK;(2) Pfizer Global Manufacturing, Global Manufacturing Services, Pfizer Inc., 235 East 42nd Street 685/6/11, New York, NY 10017, USA;(3) Cognis France, Fermentation Specialties, 185 av de Fontainebleau, F-77981 St. Fargeau-Ponthierry, France |
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| Abstract: | ![]()
The use of a rapeseed oil emulsion feed, produced by a phase inversion temperature (PIT) process, produced more biomass, gave a 3-fold increase in oil utilisation and a higher oxytetracycline titre but a higher residual oil concentration when compared to a conventional fed-batch Streptomyces rimosus process fed with crude rapeseed oil. Importantly, microbial utilisation of the surfactant was confirmed for the first time. |
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| Keywords: | Fed-batch fermentation oxytetracycline PIT micro-emulsion residual oil Streptomyces rimosus |
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